{"id":61,"date":"2022-01-27T15:00:45","date_gmt":"2022-01-27T06:00:45","guid":{"rendered":"https:\/\/bottomup-biotech.elsi.jp\/?page_id=61"},"modified":"2024-12-30T16:15:13","modified_gmt":"2024-12-30T07:15:13","slug":"achievements","status":"publish","type":"page","link":"https:\/\/bottomup-biotech.elsi.jp\/en\/achievements\/","title":{"rendered":"Research Achievements"},"content":{"rendered":"

<\/p>\n

Papers<\/h2>\n
    \n
  1. \n

    “Effective design of PEGylated polyion complex (PIC) nanoparticles for enhancing PIC internalisation in cells utilising block copolymer combinations with mismatched ionic chain lengths<\/a>“
    Fadlina Aulia, Hiroaki Matsuba, Shoya Adachi, Takumi Yamada, Ikuhiko Nakase, Teruki Nii, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura
    J. Mater. Chem. B<\/em>, 2024, in press.<\/em><\/strong><\/p>\n<\/li>\n

  2. \n

    “Preparation of cellular membrane-mimicking glycopolymer interfaces by the solvent-assisted method on QCM-D sensor chips and their molecular recognition<\/a>“
    Masanori Nagao, Tsukuru Masuda, Madoka Takai and Yoshiko Miura
    J. Mater. Chem. B<\/em>, 2024, in press.<\/em><\/strong><\/p>\n<\/li>\n

  3. \n

    “Lipid vesicle-based molecular robots<\/a>“
    Zugui Peng, Shoji Iwabuchi, Kayano Izumi, Sotaro Takiguchi, Misa Yamaji, Shoko Fujita, Harune Suzuki, Fumika Kambara, Genki Fukasawa, Aileen Cooney, Lorenzo Di Michele, Yuval Elani, Tomoaki Matsuura and Ryuji Kawano
    Lab Chip<\/em>, 2024, in press.<\/em><\/strong><\/p>\n<\/li>\n

  4. \n

    “Evolution of hierarchy and irreversibility in theoretical cell differentiation model<\/a>“
    Yoshiyuki T Nakamura, Yusuke Himeoka, Nen Saito, Chikara Furusawa
    PNAS Nexus<\/em>, 2024, 3(1), pgad454<\/strong><\/p>\n<\/li>\n

  5. \n

    “Real-time monitoring of the amyloid \u03b21\u201342 monomer-to-oligomer channel transition using a lipid bilayer system<\/a>“
    Yuri Numaguchi, Kaori Tsukakoshi, Nanami Takeuchi, Yuki Suzuki, Kazunori Ikebukuro, Ryuji Kawano
    PNAS Nexus<\/em>, 2024, 3(1), pgad437<\/strong><\/p>\n<\/li>\n

  6. \n

    “Multimolecular Competition Effect as a Modulator of Protein Localization and Biochemical Networks in Cell-Size Space<\/a>“
    Saki Nishikawa, Gaku Sato, Sakura Takada, Shunshi Kohyama, Gen Honda, Miho Yanagisawa, Yutaka Hori, Nobuhide Doi, Natsuhiko Yoshinaga, Kei Fujiwara
    Adv. Sci.<\/em>, 2023, e2308030.<\/strong><\/p>\n<\/li>\n

  7. \n

    “Multistep conformational changes leading to the gate opening of light-driven sodium pump rhodopsin<\/a>“
    Yukino Sato, Tsubasa Hashimoto, Koji Kat, Akiko Okamura, Kaito Hasegawa, Tsukasa Shinone, Yoshikazu Tanaka, Yoshiki Tanaka, Tomoya Tsukazaki, Takashi Tsukamoto, Makoto Demura, Min Yao, Takashi Kikukawa
    J. Biol. Chem.<\/em>, in press.<\/em><\/strong><\/p>\n<\/li>\n

  8. \n

    “Correlation between Self-Folding Behavior of Amphiphilic Polymers and Their Molecular Flexibility<\/a>“
    Masanori Nagao and Yoshiko Miura
    ACS Macro Lett.<\/em>, 2023, 12, 6, 733-737.<\/strong><\/p>\n<\/li>\n

  9. \n

    “Engineering metabolic cycle-inspired hydrogels with enzyme-fueled programmable transient volume changes<\/a>“
    Young Kyoung Hong, Masahiko Nakamoto and Michiya Matsusaki
    J. Mater. Chem. B<\/em>, 2023, 11, 8136-8141.<\/strong><\/p>\n<\/li>\n

  10. \n

    “Elastic Polymer Coated Nanoparticles with Fast Clearance for 19F\u2005MR Imaging<\/a>“
    Yuki Konishi, Masafumi Minoshima, Kohei Fujihara, Takayuki Uchihashi, Kazuya Kikuchi
    Angew. Chem. Int. Ed.<\/em>, 2023, 1433-7851.<\/strong><\/p>\n<\/li>\n

  11. \n

    “Iron azaphthalocyanine electrocatalysts for enhancing oxygen reduction reactions under neutral conditions and power density in microbial fuel cells<\/a>“
    Edwin Osebe Nyangau, Hiroya Abe, Yuta Nakayasu, Masaki Umetsu, Masaru Watanabe, Chika Tada
    Bioresource Technology Reports<\/em>, 2023, 101565.<\/strong><\/p>\n<\/li>\n

  12. \n

    “Structural requirements of a glycolipid MPIase for membrane protein integration<\/a>“
    Kohki Fujikawa, Youjung Han, Tsukiho Osawa, Shoko Mori, Kaoru Nomura, Maki Muramoto, Ken-ichi Nishiyama, Keiko Shimamoto
    Chem. Eur. J.<\/em>, 2023, 29(30), e202300437.<\/strong><\/p>\n<\/li>\n

  13. \n

    “Chitin- and Streptavidin-Mediated Affinity Purification Systems: A Screening Platform for Enzyme Discovery<\/a>“
    Shunsuke Kato, Koki Takeuchi, Motonao Iwaki, Kentaro Miyazaki, Kohsuke Honda, Takashi Hayashi
    Angew. Chem. Int. Ed.<\/em>, 2023, e202303764.<\/strong><\/p>\n<\/li>\n

  14. \n

    “Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations<\/a>“
    Jinbin Yang, Hiroki Kamai, Yong Wang, Yan Xu
    Small<\/em>, 2023, 2301013.<\/strong><\/p>\n<\/li>\n

  15. \n

    “A simple chemical method to nondestructively regenerate functional nanochannels for single-molecule studies<\/a>“
    Jinbin Yang, Hiroki Kamai and Yan Xu
    Sensors and Actuators B: Chemical<\/em>, 2023, 134106.<\/strong><\/p>\n<\/li>\n

  16. \n

    “Mussel-inspired interfacial ultrathin films for cellular adhesion on the wrinkled surfaces of hydrophobic fluids<\/a>“
    Hiroya Abe, Tomoya Ina, Hirokazu Kaji and Matsuhiko Nishizawa
    Polymer Journal<\/em>, 2023, 1-6.<\/strong><\/p>\n<\/li>\n

  17. \n

    “Nanopore Filter: A Method for Counting and Extracting Single DNA Molecules Using a Biological Nanopore<\/a>“
    Asuka Tada, Nanami Takeuchi, Kan Shoji, and Ryuji Kawano
    Anal. Chem.<\/em>, 2023, ASAP<\/em>.<\/strong><\/p>\n<\/li>\n

  18. \n

    “Investigation of Compatibility between DNA Replication, Transcription, and Translation for in Vitro Central Dogma<\/a>“
    Kaito Seo and Norikazu Ichihashi
    ACS Synth. Biol.<\/em>, 2023, 12, 6, 1813-1822.<\/strong><\/p>\n<\/li>\n

  19. \n

    “Self-assembled GA-Repeated Peptides as a Biomolecular Scaffold for Biosensing with MoS2 Electrochemical Transistors<\/a>“
    Hironaga Noguchi, Yoshiki Nakamura, Sayaka Tezuka, Takakazu Seki, Kazuki Yatsu, Takuma Narimatsu, Yasuaki Nakata, and Yuhei Hayamizu
    ACS Appl. Mater. Interfaces<\/em>, 2023, 15, 11, 14058\u201314066.<\/strong><\/p>\n<\/li>\n

  20. \n

    “Dynamic frustrated charge hotspots created by charge density modulation sequester globular proteins into complex coacervates<\/a>“
    Biplab K C, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura
    Chem. Sci.<\/em>, 2023, 14, 6608-6620.<\/strong><\/p>\n<\/li>\n

  21. \n

    “Spatiotemporal Control of Ice Crystallization in Supercooled Water via an Ultrashort Laser Impulse<\/a>“
    Hozumi Takahashi, Tatsuya Kono, Kosuke Sawada, Satoru Kumano, Yuka Tsuri, Mihoko Maruyama, Masashi Yoshimura, Daisuke Takahashi, Yukio Kawamura, Matsuo Uemura, Seiichiro Nakabayashi, Yusuke Mori, Yoichiroh Hosokawa, and Hiroshi Y. Yoshikawa
    J. Phys. Chem. Lett.<\/em>, 2023, 14, 19, 4394\u20134402.<\/strong><\/p>\n<\/li>\n

  22. \n

    “Flexible Glass-Based Hybrid Nanofluidic Device to Enable the Active Regulation of Single-Molecule Flows<\/a>“
    Hiroto Kawagishi, Shun-ichi Funano, Yo Tanaka, and Yan Xu
    Nano Lett.<\/em>, 2023, 23, 6, 2210-2218.<\/strong><\/p>\n<\/li>\n

  23. \n

    “Phenylazothiazoles as Visible-Light Photoswitches<\/a>“
    Runze Lin, P. K. Hashim, Saugata Sahu, Ammathnadu S. Amrutha, Nusaiba Madappuram Cheruthu, Shakkeeb Thazhathethil, Kiyonori Takahashi, Takayoshi Nakamura, Takashi Kikukawa, and Nobuyuki Tamaoki
    J. Am. Chem. Soc.<\/em>, 2023, 145, 16, 9072-9080.<\/strong><\/p>\n<\/li>\n

  24. \n

    “Foci-forming regions of pyruvate kinase and enolase at the molecular surface incorporate proteins into yeast cytoplasmic metabolic enzymes transiently assembling (META) bodies<\/a>“
    Ryotaro Utsumi, Yuki Murata, Sayoko Ito-Harashima, Misaki Akai, Natsuko Miura, Kouichi Kuroda, Mitsuyoshi Ueda, Michihiko Kataoka
    Plos one<\/em>, 2023, in press<\/em>.<\/strong><\/p>\n<\/li>\n

  25. \n

    “In Vitro Transcription\/Translation-Coupled DNA Replication through Partial Regeneration of 20 Aminoacyl-tRNA Synthetases<\/a>“
    Katsumi Hagino, Norikazu Ichihashi
    ACS Synth. Biol.<\/em>, 2023, 12, 4, 1252-1263.<\/strong><\/p>\n<\/li>\n

  26. \n

    “Increased Enzyme Loading in PICsomes via Controlling Membrane Permeability Improves Enzyme Prodrug Cancer Therapy Outcome<\/a>“
    Akinori Goto, Yasutaka Anraku, Shigeto Fukushima, Akihiro Kishimura
    Polymers<\/em>, 2023, 15, 1368.<\/strong><\/p>\n<\/li>\n

  27. \n

    “Characterization of retinal chromophore and protonated Schiff base in Thermoplasmatales archaeon heliorhodopsin using solid-state NMR spectroscopy<\/a>“
    Shibuki Suzuki, Sari Kumagai, Toshio Nagashima, Toshio Yamazaki, Takashi Okitsu, Akimori Wada, Akira Naito, Kota Katayama, Keiichi Inoue, Hideki Kandori, Izuru Kawamura
    Biophys. Chem.<\/em>, 2023, 296, 106991.<\/strong><\/p>\n<\/li>\n

  28. \n

    “Evolutionary Engineering of a Cp*Rh(III) Complex-Linked Artificial Metalloenzyme with a Chimeric \u03b2-Barrel Protein Scaffold<\/a>“
    Shunsuke Kato, Akira Onoda, Ulrich Schwaneberg, Takashi Hayashi
    J. Am. Chem. Soc.<\/em>, 2023, 145, 15, 8285-8290.<\/strong><\/p>\n<\/li>\n

  29. \n

    “Development of a Versatile Protein Labeling Tool for Live-Cell Imaging Using Fluorescent \u00df-Lactamase Inhibitors<\/a>“
    Masafumi Minoshima, Taro Umeno, Kohei Kadooka, Margaux Roux, Namiko Yamada, Kazuya Kikuchi
    Angew. Chem. Int. Ed.<\/em>, 2023, in press<\/em>.<\/strong><\/p>\n<\/li>\n

  30. \n

    “Toward nanofluidics-based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds<\/a>“
    Nattapong Chantipmanee, Yan Xu
    VIEW<\/em>, 2023, 4, 1, 20220036<\/strong>
    \u672c\u8a8c\u8868\u7d19\u306b\u63a1\u629e<\/a>\u3055\u308c\u307e\u3057\u305f<\/p>\n<\/li>\n

  31. \n

    “Cell-free expression of de novo designed peptides that form \u03b2-barrel nanopores<\/a>“
    Shoko Fujita, Izuru Kawamura, Ryuji Kawano
    ACS Nano<\/em>, 2023, 17, 4, 3358.<\/strong><\/p>\n<\/li>\n

  32. \n

    “Liposome Deformation Induced by Membrane-Binding Peptides<\/a>“
    Kayano Izumi, Chihiro Saito, Ryuji Kawano
    Micromachines<\/em>, 2023, 14, 373.<\/strong><\/p>\n<\/li>\n

  33. \n

    “Facile preparation of hexagonal nanosheets via polyion complex formation from \u03b1-helical polypeptides and polyphosphate-based molecules<\/a>“
    Asmariah Ahmad, Tomoki Maruyama, Teruki Nii, Takeshi Mori, Yoshiki Katayama. Akihiro Kishimura
    Chem comm.<\/em>, 2023, 59, 1657\u20131660.<\/strong><\/p>\n<\/li>\n

  34. \n

    “Designable peptides on graphene field-effect transistors for selective detection of odor molecules<\/a>“
    Chishu Homma, Mirano Tsukiiwa, Hironaga Noguchi, Masayoshi Tanaka, Mina Okochi, Hideyuki Tomizawa, Yoshiaki Sugizaki, Atsunobu Isobayashi, Yuhei Hayamizu
    Biosens. Bioelectron.<\/em>, 2023, 224, 115047.<\/strong><\/p>\n<\/li>\n

  35. \n

    “Emergence of growth and dormancy from a kinetic model of the Escherichia coli<\/em> central carbon metabolism<\/a>“
    Yusuke Himeoka and Namiko Mitarai
    Phys. Rev. Research<\/em>, 2022, 4, 043223.<\/strong><\/p>\n<\/li>\n

  36. \n

    “Surfactant-Assisted Purification of Hydrophobic DNA Nanostructures<\/a>“
    Shoji Iwabuchi, Shin-ichiro M. Nomura, Yusuke Sato
    ChemBioChem<\/em>, 2022, e202200.<\/strong><\/p>\n<\/li>\n

  37. \n

    “ePURE_JSBML: A tool for constructing a deterministic model of a reconstituted Escherichia coli protein translation system with a user-specified nucleic acid sequence<\/a>“
    Yoshihiro Shimizu, Naoki Tanimura, Tomoaki Matsuura
    Adv. Biology<\/em>, 2022, 2200177.<\/strong><\/p>\n<\/li>\n

  38. \n

    “Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution<\/a>“
    Rikuto Kamiura,Ryo Mizuuchi,Norikazu Ichihashi
    PLoS Comput. Biol.<\/em>,2022, 1010709.<\/strong><\/p>\n<\/li>\n

  39. \n

    “Fabrication of a polymeric inhibitor of proximal metabolic enzymes in hypoxia for synergistic Inhibition of cancer cell proliferation, survival, and migration<\/a>“
    Yuki Koba, Masahiko Nakamoto, Michiya Matsusaki
    ACS Appl. Mater. Interfaces<\/em>, 2022, 14, 46, 51790\u221251797.<\/strong><\/p>\n<\/li>\n

  40. \n

    “A peptide nanocage constructed by self-assembly of oligoproline conjugates<\/a>“
    Shogo Matsubara, Yui Okamoto, Masaru Yoshikawa, Shinya Tsukiji, Masahiro Higuchi
    Bioconj. Chem.<\/em>, 2022, 33, 10, 1785-1788.<\/strong><\/p>\n<\/li>\n

  41. \n

    “A methodology for creating thermostabilized mutants of G-protein coupled receptors by combining statistical thermodynamics and evolutionary molecular engineering<\/a>“
    Kanna Sugaya, Satoshi Yasuda, Shingo Sato, Chen Sisi, Taisei Yamamoto, Daisuke Umeno, Tomoaki Matsuura, Tomohiko Hayashi, Satoshi Ogasawara, Masahiro Kinoshita, Takeshi Murata
    Protein Sci.<\/em>, 2022, 31, 9, e4404.<\/strong><\/p>\n<\/li>\n

  42. \n

    “Three-dimensional structure of the antimicrobial peptide cecropin P1 in dodecylphosphocholine micelles and the role of the C-terminal residues<\/a>“
    Hao Gu, Takasumi Kato, Hiroyuki Kumeta, Yasuhiro Kumaki, Takashi Tsukamoto, Takashi Kikukawa, Makoto Demura, Hiroaki Ishida, Hans J. Vogel, Tomoyasu Aizawa
    ACS Omega<\/em>, 2022, 7, 36, 31924\u221231934.<\/strong><\/p>\n<\/li>\n

  43. \n

    “Protein-structure-dependent spectral shifts of near-infrared photoluminescence from locally functionalized single-walled carbon nanotubes based on avidin\u2013biotin interactions<\/a>“
    Yoshiaki Niidome, Rie Wakabayashi, Masahiro Goto, Tsuyohiko Fujigaya, Tomohiro Shiraki
    Nanoscale<\/em>, 2022, 14, 13090\u201313097.<\/strong><\/p>\n<\/li>\n

  44. \n

    “Molecular crowding elicits the acceleration of enzymatic crosslinking of macromolecular substrates<\/a>“
    Ryo Sato, Kosuke Minamihata, Rie Wakabayashi, Masahiro Goto, Noriho Kamiya
    Org. Biomol. Chem.<\/em>, 2022, 21, 306\u2013314.<\/strong><\/p>\n<\/li>\n

  45. \n

    “Effects of pulse duration on laser-induced crystallization of urea from 300 to 1200 fs: impact of cavitation bubbles on crystal nucleation<\/a>“
    Yuka Tsuri, Mihoko Maruyama, Katsuo Tsukamoto, Hiroaki Adachi, Kazufumi Takano, Shigeyoshi Usami, Masayuki Imanishi, Masashi Yoshimura, Hiroshi Y. Yoshikawa, Yusuke Mori
    Appl. Phys. A<\/em>, 2022, 128, 803.<\/strong><\/p>\n<\/li>\n

  46. \n

    “Synthesis of well-defined cyclic glycopolymers and the relationship between their physical properties and their interaction with lectins<\/a>“
    Masanori Nagao, Yu Hoshino, Yoshiko Miura
    Polym. Chem.<\/em>, 2022, 13, 5453\u20135457.<\/strong><\/p>\n<\/li>\n

  47. \n

    “Mechanical guidance of self-condensation patterns of differentiating progeny<\/a>“
    Takahisa Matsuzaki, Yuko Shimokawa, Hiroyuki Koike, Masaki Kimura, Yuma Kawano, Nao Okuma, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa
    iScience<\/em>, 2022, 25, 10, 105109.<\/strong><\/p>\n<\/li>\n

  48. \n

    “Practice of responsible research and innovation in the formulation and revision of ethical principles of molecular robotics in Japan<\/a>“
    Ken Komiya, Ryuma Shineha, Naoto Kawahara
    SN Appl. Sci.<\/em>, 2022, 4, 305.<\/strong><\/p>\n<\/li>\n

  49. \n

    “Experimental evidence for the correlation between RNA structural fluctuations and the frequency of beneficial mutations<\/a>“
    Yutaro Maeda, Ryo Mizuuchi, Shuji Shigenobu, Atsushi Shibai, Hazuki Kotani, Chikara Furusawa, Norikazu Ichihashi
    RNA<\/em>, 2022, 28, 12, 1659-1667.<\/strong><\/p>\n<\/li>\n

  50. \n

    “Controlling the periodicity of a reaction\u2013diffusion wave in artificial cells by a two-way energy supplier<\/a>“
    Sakura Takada, Natsuhiko Yoshinaga, Nobuhide Doi, Kei Fujiwara
    ACS Nano<\/em>, 2022, 16, 10, 16853\u221216861.<\/strong><\/p>\n<\/li>\n

  51. \n

    “Mutations conferring SO4<\/sub>2\u2212<\/sup> pumping ability on the cyanobacterial anion pump rhodopsin and the resultant unique features of the mutant<\/a>“
    Yuhei Doi, Jo Watanabe, Ryota Nii, Takashi Tsukamoto, Makoto Demura, Yuki Sudo, Takashi Kikukawa
    Sci. Rep.<\/em>, 2022, 12, 16422.<\/strong><\/p>\n<\/li>\n

  52. \n

    “A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation<\/a>“
    Sachio Suzuki, Akinobu Nakamura, Yuka Hatano, Masaru Yoshikawa, Tatsuyuki Yoshii, Shunsuke Sawada, Kyoko Atsuta-Tsunoda, Kazuhiro Aoki, Shinya Tsukiji
    Cell Chem. Biol.<\/em>, 2022, 29, 9, 1446-1464.e10.<\/strong><\/p>\n<\/li>\n

  53. \n

    “Reisomerization of retinal represents a molecular switch mediating Na+<\/sup> uptake and release by a bacterial sodium-pumping rhodopsin<\/a>“
    Tomotsumi Fujisawa, Kouta Kinoue, Ryouhei Seike, Takashi Kikukawa, Masashi Unno
    J. Biol. Chem.<\/em>, 2022, 298, 9, 102366.<\/strong><\/p>\n<\/li>\n

  54. \n

    “Biomacromolecule-fueled transient volume phase transition of a hydrogel<\/a>“
    Masahiko Nakamoto, Shiro Kitano, Michiya Matsusaki
    Angew. Chem. Int. Ed.<\/em>, 2022, 61, 33,e202205125.<\/strong><\/p>\n<\/li>\n

  55. \n

    “Role of a bacterial glycolipid in Sec-independent membrane protein insertion<\/a>“
    Kaoru Nomura, Shoko Mori, Kohki Fujikawa, Tsukiho Osawa, Shugo Tsuda, Kumiko Yoshizawa-Kumagaye, Shun Masuda, Hideki Nishio, Taku Yoshiya, Takao Yoda, Masafumi Shionyu, Tsuyoshi Shirai, Ken-ichi Nishiyama, Keiko Shimamoto
    Sci. Rep.<\/em>, 2022, 12, 12231.<\/strong><\/p>\n<\/li>\n

  56. \n

    “Transfer RNA synthesis-coupled translation and DNA replication in a reconstituted transcription\/translation system<\/a>“
    Ryota Miyachi, Yoshihiro Shimizu, Norikazu Ichihashi
    ACS Synth. Biol.<\/em>, 2022, 11 , 8,2791-2799.<\/strong><\/p>\n<\/li>\n

  57. \n

    “One-step preparation of cell-free ATP regeneration module based on non-oxidative glycolysis using thermophilic enzymes<\/a>“
    Gladwin Suryatin Alim, Kenji Okano, Kohsuke Honda
    ChemBioChem<\/em>, 2022, 23, 16,e202200210.<\/strong><\/p>\n<\/li>\n

  58. \n

    “Pattern recognition of microRNA expression in body fluids using nanopore decoding at subfemtomolar concentrations<\/a>“
    Nanami Takeuchi, Moe Hiratani, Ryuji Kawano
    JACS Au<\/em>, 2022, 2, 9, 1829\u20131838.<\/strong>
    \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u30ca\u30ce\u30dd\u30a2\u3092\u7528\u3044\u305f\u8840\u4e2d\u304c\u3093\u30de\u30fc\u30ab\u30fc\u306e\u30d1\u30bf\u30fc\u30f3\u8b58\u5225\u306b\u6210\u529f\uff01\u2015DNA\u30b3\u30f3\u30d4\u30e5\u30fc\u30c6\u30a3\u30f3\u30b0\u6280\u8853\u306b\u3088\u308b\u4e26\u5217\u8a08\u7b97\u3092\u5229\u7528\u2015, \u6771\u4eac\u8fb2\u5de5\u5927\u5b66
    \u30e1\u30c7\u30a3\u30a2\u5831\u9053\uff1a\u65e5\u672c\u7d4c\u6e08\u65b0\u805e, EurekAlert!, Bioengineer.org, SCIENMAG, TECH+, GEN, ecancer, Jano.es, eBiotrade, List23, tetracyclined7k, AZoLifeSciences<\/p>\n<\/li>\n

  59. \n

    “A photoactivatable self-localizing ligand with improved photosensitivity for chemo-optogenetic control of protein localization in living cells<\/a>“
    Tatsuyuki Yoshii, Choji Oki, Shinya Tsukiji
    Bioorg. Med. Chem. Lett.<\/em>, 2022, 72, 128865.<\/strong><\/p>\n<\/li>\n

  60. \n

    “A protocol to construct RNA-protein devices for photochemical translational regulation of synthetic mRNAs in mammalian cells<\/a>“
    Hideyuki Nakanishi, Tatsuyuki Yoshii, Shinya Tsukiji, Hirohide Saito
    STAR Protoc.<\/em>, 2022, 101451.<\/strong><\/p>\n<\/li>\n

  61. \n

    “One-step preparation of cell-free ATP regeneration module based on non-oxidative glycolysis using thermophilic enzymes<\/a>“
    Gladwin Suryatin Alim, Kenji Okano, Kohsuke Honda
    ChemBioChem,<\/em>, 2022, e202200210.<\/strong><\/p>\n<\/li>\n

  62. \n

    “Fluorescent hydrogel based on self-assembling acridonylalanine-phenylalanine<\/a>“
    Yuzuha Araki, Hiroki Shirakata, Tetsuya Nakagawa, Takashi Ubukata, Yasushi Yokoyama, Izuru Kawamurabr
    Chem. Lett.<\/em>, 2022, 51, 7, 687\u2013689.<\/strong><\/p>\n<\/li>\n

  63. \n

    “Functionalized silicone elastomer via alkaline solution to coat phosphorylcholine-based copolymer containing organosilane to improve hemocompatibility for medical devices<\/a>“
    Fang-Yu Chou, Shintaro Hara, Kazuto Uchida, Youichi Matsuo, Tsukuru Masuda, Ryo Yokoi, Toshiya Ono, Masaki Anraku, Takashi Isoyama, Madoka Takai
    Front. Mater.<\/em>, 2022, 9, 877755.<\/strong><\/p>\n<\/li>\n

  64. \n

    “Construction of a reduction-responsive DNA microsphere using a reduction-cleavable spacer based on a nitrobenzene scaffold<\/a>“
    Sayuri L. Higashi, Ayaka Isogami, Junko Takahashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G.N. Suzuki, Shunsuke Sawada, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda
    Chem. Eur. J.<\/em>, 2022, 17, 10, e202200142.<\/strong><\/p>\n<\/li>\n

  65. \n

    “Photoreaction pathways of bacteriorhodopsin and its D96N mutant as revealed by in-situ photoirradiation solid-state NMR<\/a>“
    Arisu Shigeta, Yuto Otani, Ryota Miyasa, Yoshiteru Makino, Izuru Kawamura, Takashi Okitsu, Akimori Wada, Akira Naito
    Membranes<\/em>, 2022, 12, 3, 279.<\/strong><\/p>\n<\/li>\n

  66. \n

    “Silver-loaded carboxymethyl cellulose nonwoven sheet with controlled counterions for infected wound healing<\/a>“
    Seiichi Ohta, Kento Mitsuhashi, Arvind K. Singh Chandel, Pan Qi, Noriko Nakamura, Akiko Nakamichi, Hiromi Yoshida, Gento Yamaguchi, Yuichi Hara, Ryo Sasaki, Masaya Fuke, Madoka Takai, Taichi Ito
    Carbohydr. Polym.<\/em>, 2022, 286, 119289.<\/strong><\/p>\n<\/li>\n

  67. \n

    “Cell-free synthesis of human endothelin receptors and its application to ribosome display<\/a>“
    Hiroki Nakai, Kinuka Isshiki, Masato Hattori, Hiromasa Maehira, Tatsumi Yamaguchi, Keiko Masuda, Yoshihiro Shimizu, Takayoshi Watanabe, Takahiro Hohsaka, Wataru Shihoya, Osamu Nureki, Yasuhiko Kato, Hajime Watanabe, and Tomoaki Matsuura
    Anal. Chem.<\/em>, 2022, 94, 9, 3831\u20133839.<\/strong><\/p>\n<\/li>\n

  68. \n

    “Functional visualization of NK cell-mediated killing of metastatic single tumor cells<\/a>“
    Hiroshi Ichise, Shoko Tsukamoto, Tsuyoshi Hirashima, Yoshinobu Konishi, Choji Oki, Shinya Tsukiji, Satoshi Iwano, Atsushi Miyawaki, Kenta Sumiyama, Kenta Terai, Michiyuki Matsuda
    eLife<\/em>, 2022, 11, e76269.<\/strong><\/p>\n<\/li>\n

  69. \n

    Review “Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales<\/a>“
    Sasikarn Seetasang, Yan Xu
    J. Mater. Chem. B<\/em>,2022, 10, 14, 2323\u20132337.<\/strong><\/p>\n<\/li>\n

  70. \n

    Review “Condensate Formation by Metabolic Enzymes in Saccharomyces cerevisiae<\/em><\/a>“
    Natsuko Miura
    Microorganisms<\/em>, 2022, 10, 2, 232.<\/strong><\/p>\n<\/li>\n

  71. \n

    “A biomimetic anti-biofouling coating in nanofluidic channels<\/a>“
    Sumire Fukuda, Yan Xu
    J. Mater. Chem. B<\/em>, 2022, 10, 14, 2481\u20132489.<\/strong>
    Journal of Materials Chemistry B HOT Papers\u306b\u9078\u51fa\u3055\u308c\u305f<\/p>\n<\/li>\n

  72. \n

    “Chimeric mutants of staphylococcal hemolysin, which actas both one-component and two-component hemolysin, created by grafting the stem domain<\/a>“
    Nouran Ghanem, Natsuki Kanagami, Takashi Matsui, Kein Takeda, Jun Kaneko, Yasuyuki Shiraishi, Christian A. Choe, Tomomi Uchikubo-Kamo, Mikako Shirouzu, Tsubasa Hashimoto, Tomohisa Ogawa, Tomoaki Matsuura, Po-Ssu Huang, Takeshi Yokoyama, Yoshikazu Tanaka
    FEBS J.<\/em>, 2022, 289, 12, 3505\u20133520.<\/strong><\/p>\n<\/li>\n

  73. \n

    Review “Design of biointerfaces composed of soft materials using controlled radical polymerization<\/a>“
    Tsukuru Masuda, Madoka Takai
    J. Mater. Chem. B<\/em>, 2022, 10, 10, 1473\u20131485.<\/strong><\/p>\n<\/li>\n

  74. \n

    “Photoswitching of 5-phenylazopyrimidines in crystalline powders and thin films<\/a>“
    Eli\u0161ka Proch\u00e1zkov\u00e1, Juraj Filo, Lucie Mu\u017e\u00edkov\u00e1 \u010cechov\u00e1, Martin Dra\u010d\u00ednsk\u00fd, Ivana C\u00edsa\u0159ov\u00e1, Zlatko Janeba, Izuru Kawamura, Akira Naito, Peter N\u00e1da\u017edy, Peter \u0160iffalovi\u010d, Marek Cig\u00e1\u0148
    Dyes Pigm.<\/em>, 2022, 199, 110066.<\/strong><\/p>\n<\/li>\n

  75. \n

    “Cell adhesion and migration on thickness gradient bilayer polymer brush surfaces: effects of properties of polymeric materials of the underlayer<\/a>“
    Zahra Afzali, Taishi Matsushita, Akinori Kogure, Tsukuru Masuda, Tomoyuki Azuma, Keiichiro Kushiro, Toshihiro Kasama, Ryo Miyake, Madoka Takai
    ACS Appl. Mater. Interfaces<\/em>, 2022, 14, 2, 2605\u20132617.<\/strong><\/p>\n<\/li>\n

  76. \n

    Review “Recent advances in research on biointerfaces: From cell surfaces to artificial interfaces<\/a>“
    Katsutoshi Hori, Shogo Yoshimoto, Tomoko Yoshino, Tamotsu Zako, Gen Hirao, Satoshi Fujita, Chikashi Nakamura, Ayana Yamagishi, Noriho Kamiya
    J. Biosci. Bioeng.<\/em>, 2022, 133, 3, 195\u2013207.<\/strong><\/p>\n<\/li>\n

  77. \n

    “Two-dimensional imaging of a model pharmaceutical dosage tablet using a scanning vibrational circular dichroism system<\/a>“
    Hisako Sato, Sumio Aisawa, Honoka Ida, Masaru Shimizu, Keisuke Watanabe, Jun Koshobu, Jun Yoshida, Izuru Kawamura
    Chem. Lett.<\/em>, 2022, 51, 2, 205-207.<\/strong><\/p>\n<\/li>\n

  78. \n

    “Nanofluidics for sub-single cellular studies: Nascent progress, critical technologies, and future perspectives<\/a>“
    Jinbin Yang, Yan Xu
    Chin. Chem. Lett.<\/em>, 2022, 33, 6, 2799.<\/strong><\/p>\n<\/li>\n

  79. \n

    “De novo design of a nanopore for single molecule detection that incorporates a \u03b2-hairpin peptide<\/a>“
    Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, Ryuji Kawano
    Nature Nanotechnol.<\/em>, 2022, 17, 67.<\/strong><\/p>\n<\/li>\n

  80. \n

    “Identification of conditions for efficient cell-sized liposome preparation using commercially available reconstituted in vitro transcription-translation system<\/a>“
    Atsuko Uyeda, Sabrina Gali\u00f1anes Reyes, Takashi Kanamori, Tomoaki Matsuura
    J. Biosci. Bioeng.<\/em>, 2022, 133, 2, 181.<\/strong><\/p>\n<\/li>\n

  81. \n

    “A Dual Promoter System to Monitor IFN-\u03b3 Signaling in vivo at Single-cell Resolution<\/a>“
    Taisei Tanaka, Yoshinobu Konishi, Hiroshi Ichise, Shinya Tsukiji, Michiyuki Matsuda, Kenta Terai
    Cell Struct. Funct.<\/em>, 2022, 46, 2, 103<\/strong><\/p>\n<\/li>\n

  82. \n

    “pH-responsive water-soluble polymer carriers for cell-selective metabolic sialylation labeling<\/a>“
    Tingbi Zhao, Tsukuru Masuda, Madoka Takai
    Anal. Chem.<\/em>, 2021, 93, 46, 15420.<\/strong><\/p>\n<\/li>\n

  83. \n

    Viewpoint \u201c Modularly built synthetic membraneless organelles enabling targeted protein sequestration and release<\/a>“
    Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Masaru Yoshikawa, Shinya Tsukiji
    Biochemistry<\/em>, 2021, 60, 44, 3273.<\/strong><\/p>\n<\/li>\n

  84. \n

    “Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration<\/a>“
    Shuhao Lin, Daiki Hirayama, Gembu Maryu, Kimiya Matsuda, Naoya Hino, Eriko Deguchi, Kazuhiro Aoki, Ryo Iwamoto, Kenta Terai, Michiyuki Matsuda
    Life Sci. Alliance<\/em>, 2021, 5, e202101206.<\/strong><\/p>\n<\/li>\n

  85. \n

    “Fabrication of nanoscale gas\u2013liquid interfaces in hydrophilic\/hydrophobic nanopatterned nanofluidic channels<\/a>“
    Hiroto Kawagishi, Shuichi Kawamata, Yan Xu
    Nano Lett.<\/strong><\/em>, 2021<\/strong><\/span>, 21<\/span>, 24<\/span>, 10555.<\/span><\/strong>
    <\/a>\u63b2\u8f09\u53f7\uff082021\u5e7421\u5dfb24\u53f7\uff09\u306e\u8868\u7d19\u306b\u63a1\u629e
    <\/span>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u3067\u7269\u8cea\u306e\u6fc3\u7e2e\u52b9\u679c\u3092\u767a\u898b\u2015\u30ca\u30ce\u6d41\u4f53\u30c7\u30d0\u30a4\u30b9\u306b\u3088\u308b\u8d85\u5fae\u5c0f\u6c17\u6db2\u754c\u9762\u306e\u4f5c\u88fd\u3068\u52b9\u679c\u2015, \u5927\u962a\u5e9c\u7acb\u5927\u5b66\u30fbJST
    \u30e1\u30c7\u30a3\u30a2\u5831\u9053\uff1a\u65e5\u520a\u5de5\u696d\u65b0\u805e, EurekAlert!, Asia Research News, Phys.org, Nanowerk, chemeurope.com, SCIENMAG, True Viral News, Mirage News<\/p>\n<\/li>\n<\/ol>\n

    Commercialized, patents<\/h2>\n
      \n
    1. \n

      2022.07.14
      A01 Tsukiji group
      Reagent for inducing membrane localization of proteins\u300cSLIPT-PM\u300don sale\uff08Funakoshi\uff09
      https:\/\/www.funakoshi.co.jp\/contents\/70609<\/a>
      https:\/\/www.funakoshi.co.jp\/contents\/70604<\/a><\/p>\n<\/li>\n<\/ol>\n

      Press Releases & Media Coverage<\/h2>\n
        \n
      1. \n

        Kasano group\uff1a<\/strong>JACS Au<\/strong>related<\/strong><\/p>\n

        Press Releases<\/strong>
        Successful Pattern Discrimination of Cancer Markers in Blood Using Nanopores! -Using Parallel Computing with DNA Computing Technology\u2015, TUAT<\/em><\/strong>,\u00a0
        https:\/\/www.tuat.ac.jp\/outline\/disclosure\/pressrelease\/2022\/20220627_01.html<\/a><\/p>\n

        Media coverage<\/strong>
        Tokyo University of Agriculture and Technology succeeded in identifying patterns of cancer markers in blood using nanopores., Nikkei Net<\/em><\/strong>, 27 Jun 2022,\u00a0
        https:\/\/www.nikkei.com\/article\/DGXZRSP635247_X20C22A6000000\/<\/a><\/p>\n

        Detection of cancer biomarkers from blood samples using nanopore-based DNA computing technology, EurekAlert!<\/em><\/strong>, 27 Jun 2022
        https:\/\/www.eurekalert.org\/news-releases\/957090<\/a><\/p>\n

        Detection of cancer biomarkers from blood samples using nanopore-based DNA computing technology, Bioengineer.org<\/em><\/strong>, 27 Jun 2022
        https:\/\/bioengineer.org\/detection-of-cancer-biomarkers-from-blood-samples-using-nanopore-based-dna-computing-technology\/<\/a><\/p>\n

        Detection of cancer biomarkers from blood samples using nanopore-based DNA computing technology, ScienMag<\/em><\/strong>, 27 Jun 2022
        https:\/\/scienmag.com\/detection-of-cancer-biomarkers-from-blood-samples-using-nanopore-based-dna-computing-technology\/<\/a><\/p>\n

        TUAT succeeded in identifying cholangiocarcinoma by DNA computing and nanopore measurement., TECH+<\/em><\/strong>, 28 Jun 2022
        https:\/\/news.mynavi.jp\/techplus\/article\/20220628-2382598\/<\/a><\/p>\n

        Nanopore Technology Detects Cancer Biomarkers from Patients\u2019 Blood, GEN<\/em>, 28 Jun 2022<\/strong>
        https:\/\/www.genengnews.com\/topics\/translational-medicine\/biomarkers\/nanopore-technology-detects-cancer-biomarkers-from-patients-blood\/<\/a><\/p>\n

        Detection of cancer biomarkers from blood samples using nanopore-based DNA computing technology, ecancer<\/em>, <\/strong>28 Jun 2022
        https:\/\/ecancer.org\/en\/news\/22000-detection-of-cancer-biomarkers-from-blood-samples-using-nanopore-based-dna-computing-technology<\/a><\/p>\n

        Nuevo m\u00e9todo para detectar biomarcadores de c\u00e1ncer con muestras de sangre, Jano<\/em><\/strong>, 29 Jun 2022\u00a0
        https:\/\/www.jano.es\/noticia-nuevo-metodo-detectar-biomarcadores-cancer-33440<\/a><\/p>\n

        \u5229\u7528\u7eb3\u7c73\u5b54DNA\u6280\u672f\u4ece\u8840\u6db2\u6837\u672c\u4e2d\u68c0\u6d4b\u764c\u75c7\u751f\u7269\u6807\u5fd7\u7269, ebiotrade<\/em><\/strong>, 29 Jun 2022
        https:\/\/www.ebiotrade.com\/newsf\/2022-6\/20220628002541949.htm<\/a><\/p>\n

        Cancer Biomarkers are detected from patients\u2019 blood using nanopore technology, list23<\/em><\/strong>, 29 Jun 2022
        https:\/\/list23.com\/936881-cancer-biomarkers-are-detected-from-patients-blood-using-nanopore-technology\/<\/a><\/p>\n

        Nanopore Technology Detects Cancer Biomarkers from Patients\u2019 Blood, tetracyclined7k<\/em>, 29 Jun 2022<\/strong>
        https:\/\/tetracyclined7k.com\/nanopore-technology-detects-cancer-biomarkers-from-patients-blood\/<\/a><\/p>\n

        Researchers use nanopore-based DNA computing technology to detect cancer, AZO Life Sciences<\/em><\/strong>, 1 Jul 2022
        https:\/\/www.azolifesciences.com\/news\/20220701\/Researchers-use-nanopore-based-DNA-computing-technology-to-detect-cancer.aspx<\/a><\/p>\n<\/li>\n

      2. \n

        Xu group\uff1a<\/strong>Nano Lett<\/strong>related<\/strong><\/p>\n

        Press Releases<\/strong>
        “Discovery of Material Concentration Effects at the Nanoscale – Fabrication and Effects of Ultra-Micro Gas-Liquid Interfaces Using Nanofluidic Devices”\u3001Joint press release from Osaka Prefecture University and JST\uff08Oct\/14\/2021)<\/p>\n

        \u25bcOsaka Prefecture University website
        https:\/\/www.osakafu-u.ac.jp\/press-release\/pr20211014_3\/<\/a><\/p>\n

        \u25bcJST website
        https:\/\/www.jst.go.jp\/pr\/announce\/20211014-3\/index.html<\/a><\/p>\n

        \u25bcOsaka Public University
        https:\/\/www.upc-osaka.ac.jp\/new-univ\/research\/press_release\/<\/a><\/p>\n

        \u25bcOsaka Prefecture University Twitter
        https:\/\/twitter.com\/OsakaPrefUniv\/status\/1448544485890166788<\/a><\/p>\n

        \u25bcOsaka Prefecture University Facebook
        https:\/\/www.facebook.com\/OsakaPrefectureUniv\/posts\/267661358698236<\/a><\/p>\n

        \u25bcYouTube
        https:\/\/www.youtube.com\/watch?v=ggQIXIDelgQ<\/a><\/p>\n

        Media coverage<\/strong>
        Osaka Prefectural Univ. succeeds in fabricating nanoscale ultra-small gas-liquid interfaces with high precision and uniformity,Nikkan Kogyo Shimbun , Electric version\u3001(Oct\/15\/2021)
        https:\/\/www.nikkan.co.jp\/spaces\/view\/0061628<\/a><\/p>\n

        First controllable nanoscale gas-liquid interface fabricated
        EurekAlert!
        https:\/\/www.eurekalert.org\/news-releases\/931973<\/a><\/p>\n

        Asia Research News
        https:\/\/www.asiaresearchnews.com\/content\/first-controllable-nanoscale-gas-liquid-interface-fabricated<\/a><\/p>\n

        Phys.orgPhys.org
        https:\/\/phys.org\/news\/2021-10-nanoscale-gas-liquid-interface-fabricated.html<\/a><\/p>\n

        Nanowerk
        https:\/\/www.nanowerk.com\/nanotechnology-news2\/newsid=58952.php<\/a><\/p>\n

        Chem Europe
        https:\/\/www.chemeurope.com\/en\/news\/1173219\/first-controllable-nanoscale-gas-liquid-interface-fabricated.html<\/a><\/p>\n

        ScienMag
        https:\/\/scienmag.com\/first-controllable-nanoscale-gas-liquid-interface-fabricated\/<\/a><\/p>\n

        True Viral News
        https:\/\/trueviralnews.com\/52861-first-controllable-nanoscale-gas-liquid-interface-fabricated.html<\/a><\/p>\n

        Mirage News
        https:\/\/www.miragenews.com\/first-controllable-nanoscale-gas-liquid-655001\/<\/a><\/p>\n

        Nano Letters\u306eOfficial Twitter\u306b\u3066\u7d39\u4ecb, (Nov\/6\/2021)
        https:\/\/mobile.twitter.com\/NanoLetters\/status\/1456697932716154883<\/a><\/p>\n

        The research results were published in Chinese Science Media Chemistry and Materials Chemistry., (Nov\/22\/2021)
        https:\/\/mp.weixin.qq.com\/s\/0aYt3dUtEerytmr3TKnm4A<\/a><\/p>\n

        Research Results on Nanofluidic Devices for Fabrication of Nanoscale Ultramicro Gas-Liquid Interfaces Graced the Cover of Nano Letters (Volume 21, Issue 24, 2021), (Dec\/22\/2021)
        https:\/\/pubs.acs.org\/pb-assets\/images\/_journalCovers\/nalefd\/nalefd_v021i024-3.jpg?0.4156400251492782<\/a><\/p>\n<\/li>\n

      3. \n

        Xu group\uff1a<\/strong>J Mater Chem B<\/strong>related<\/strong><\/p>\n

        “A biomimetic anti-biofouling coating in nanofluidic channels” was selected as HOT Paper of Journal of Materials Chemistry, (Jan\/20\/2022)
        https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/tb\/d1tb02627e<\/a><\/p>\n<\/li>\n<\/ol>\n

        <\/p>","protected":false},"excerpt":{"rendered":"

        <\/h2>\n